Case Control Gwas Sample Size. Represent an arguably more natural data set for exploring genetic causes of disease. The sample size when it comes to power considerations.
Family data often available from previous linkage studies. Download the CC-GWASR and CC-GWAS-parameterstxt files from this github page. It depends a lot on the genetic architecture of the trait there is if its controlled by few genes.
To the best I know there is no well-grounded method to define sample size on GWAS studies.
Dec 18 2018 ADHD casecontrol genome-wide association analysis. Concerns with study design power and sample size and analysis are reviewed. The sample size when it comes to power considerations. Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies Nat Genet.
