Can A Non Inferiority Trial Show Superiority. Superiority trials are always used when comparisons are made to placebo or vehicle treatments. In noninferiority trials if the 95 CI excludes both the noninferiority margin and the null value no difference between experimental and control it is reasonable to conclude that the experimental treatment is superior.
The Case For Non Inferiority A B Tests Analytics Toolkit Com from blog.analytics-toolkit.com
The comparison for a superiority test is made. μ 1 μ 0 vs. Jan 01 2011 Non-inferiority studies are used to show that a minimum level of efficacy has been achieved.
However it must be noted that there are potential implications in making such post-hoc changes which wont be mentioned here but if you are interested our statisticians strongly recommend the July 2000 EMA report titled Points to Consider on Switching between Superiority.
Often a nonsignificant superiority test is wrongly interpreted as proof of no. Feb 17 2010 Non-inferiority Margin Non-inferiority margin was traditionally chosen as. In some situations the new treatment may not be superior to the existing treatment at all if so it will be impossible to show it is superior. Trials which compare treatments may not be designed to show that one treatment is superior.
